Renin inhibitors containing statine or derivatives thereof

Details Renin inhibitors containing statine or derivatives thereof Renin inhibitors containing statine or derivatives thereof

C - Chemistry, Metallurgy

07

K

530/7.02, 167/10

C07K 7/02 (2006.01) C07K 5/02 (2006.01)

Patent

CA 1254699

RENIN INHIBITORS CONTAINING STATINE OR DERIVATIVES THEREOF Abstract A series of novel polypeptides and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the angiotensinogen - cleaving action of the enzyme renin. Of particular interest are compounds possessing the N-terminal sequence -Pro-Phe-His-Cyclostatine-Lys-, with the terminal proline nitrogen bonded to an amino-protecting acyl moiety.

476191

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