C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.02, 167/10
C07K 7/02 (2006.01) C07K 5/02 (2006.01)
Patent
CA 1254699
RENIN INHIBITORS CONTAINING STATINE OR DERIVATIVES THEREOF Abstract A series of novel polypeptides and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the angiotensinogen - cleaving action of the enzyme renin. Of particular interest are compounds possessing the N-terminal sequence -Pro-Phe-His-Cyclostatine-Lys-, with the terminal proline nitrogen bonded to an amino-protecting acyl moiety.
476191
Bindra Jasjit S.
Kleinman Edward F.
Rosati Robert L.
Limited Pfizer
Smart & Biggar
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