Renin-inhibitory di-, tri-, and tetrapeptides

Details Renin-inhibitory di-, tri-, and tetrapeptides Renin-inhibitory di-, tri-, and tetrapeptides

C - Chemistry, Metallurgy

07

K

167/103, 530/5.0

C07K 5/04 (2006.01) A61K 38/04 (2006.01) A61K 38/55 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2011327

004/FSC6 17757 TITLE OF THE INVENTION RENIN-INHIBITORY DI-, TRI-, AND TETRAPEPTIDES ABSTRACT OF THE DISCLOSURE Renin-inhibitory di-, tri-, and tetrapeptides of the formula I: A-B-E-G-T-J in which A is heterocyclic, substituted heterocyclic etc; B is -N(A1)CH[(CH2)2R3]CO- E is absent or is -N(A2)CH[(CH2)2R4]CO-; G is Image etc and 004/FSC6 - i - 17757 J is -Y-(CH2)[CH(R5)]y-(CH2)z-R10 and pharmaceutically acceptable salts thereof are disclosed. These compounds inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems which employ these novel peptites.

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