Reovirus for the treatment of neoplasia

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/76 (2006.01)

Patent

CA 2283280

Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain bearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovitus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

Cette invention se rapporte à des procédés de traitement des néoplasies, par administration de réovirus à un néoplasme à médiation Ras, et à l'utilisation de tels réovirus pour produire un médicament servant au traitement des néoplasies. Le réovirus est administré de façon à finir par entrer en contact direct avec les cellules du néoplasme. Des réovirus humains, des réovirus de mammifères non humains et/ou des réovirus aviaires peuvent être utilisés. Si le réovirus est un réovirus humain, le type 1 (souche Lang par exemple), le type 2 (souche Jones par exemple), le type 3 (souche Dearing ou souche Abney par exemple) ainsi que d'autres sérotypes ou souches de réovirus peuvent être utilisés. On peut également utiliser des combinaisons de plus d'un type et/ou souche de réovirus, ainsi que des réovirus provenant de différentes espèces animales. Aussi bien des néoplasmes solides que des néoplasmes hématopoïétiques peuvent ainsi être traités.

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