Reoviruses having modified sequences

Details Reoviruses having modified sequences Reoviruses having modified sequences

C - Chemistry, Metallurgy

12

N

C12N 15/46 (2006.01) A61K 35/76 (2006.01) A61P 35/00 (2006.01) C07K 14/14 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2678721

The invention provides for modified reovirus nucleic acid sequences and modified reovirus polypeptide sequences as well as reoviruses containing such modified nucleic acid or polypeptide sequences. The invention also provides for pharmaceutical compositions that include reoviruses having a modified sequence as well as methods of making and using such reoviruses.

L'invention porte sur des séquences d'acide nucléique modifiées de réovirus et sur des séquences polypeptidiques modifiées de réovirus ainsi que sur des réovirus contenant de telles séquences d'acide nucléique ou polypeptidiques modifiées. L'invention porte également sur des compositions pharmaceutiques qui comprennent des réovirus ayant une séquence modifiée, ainsi que sur des procédés de fabrication et d'utilisation de tels réovirus.

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