Repair of nerve damage

Details Repair of nerve damage Repair of nerve damage

A - Human Necessities

61

K

A61K 38/30 (2006.01) A61K 9/00 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 14/65 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2407698

The invention provides use of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform comprising amino acid sequences encoded by nucleic acid sequences of IGF-I exons 4,5 and 6 and in the reading frame of MGF and having the ability to reduce motoneurone loss by 20% or greater in response to nerve avulsion in the manufacture of a medicament for the treatment of nerve damage by localisation of MGF at the site of the damage.

L'invention concerne une isoforme du facteur de croissance semblable à l'insuline (IGF-I) MGF (facteur de croissance mécanique) comprenant des séquences d'acides aminés codées par des séquences d'acide nucléique des exons 4,5 et 6 de l'IGF-1 dans le cadre de lecture du MGF, et possédant la capacité de réduire la perte des motoneurones de 20 % ou plus en réponse à l'avulsion des nerfs, utilisée dans la fabrication d'un médicament servant à traiter les lésions nerveuses par la localisation du MGF sur le site de la lésion.

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