Replication-competent herpes simplex virus mediates...

Details Replication-competent herpes simplex virus mediates... Replication-competent herpes simplex virus mediates...

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 35/76 (2006.01) A61K 39/00 (2006.01) A61K 39/245 (2006.01) C07K 14/035 (2006.01) C12N 7/01 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2193491

A method for killing malignant brain tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with defective expression of the .gamma.34,5 gene and the ribonucleotide reductase gene, specifically destroys tumor cells, is hypersensitive to anti-viral agents, and yet is not neurovirulent.

Procédé permettant de tuer in vivo des cellules tumorales malignes du cerveau, consistant à mettre ces cellules en contact avec des vecteurs du virus de l'herpès simplex à compétition de réplication. Un vecteur du virus de l'herpès simplex à compétition de réplication, présentant une expression défectueuse du gène .gamma.34.5 et du gène de ribonucléotide réductase, détruit spécifiquement les cellules tumorales, et est hypersensible aux agents antiviraux sans être neurovirulent.

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