Replication deficient adenovirus vectors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2398842

The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific strategy for making adenoviral vector preparations substantially free of replication competent "helper" virus. The helper virus-free preparations provide novel pharmaceutical compositions substantially free of helper virus for use in gene transfer and gene therapy.

L'invention concerne de nouveaux vecteurs adénovirus déficients pour la réplication ainsi que des procédés de préparation et d'utilisation de ces virus. L'invention concerne également des systèmes de vecteurs et des assortiments de matériel dans lesquels une stratégie spécifique fondée sur le sérotype est appliquée pour rendre les préparations de vecteurs adénoviraux sensiblement exempts de virus auxiliaires à capacité de réplication. Ces préparations exemptes de virus auxiliaires permettent d'obtenir de nouvelles compositions pharmaceutiques sensiblement exemptes de virus auxiliaires, convenant pour le transfert de gènes et la thérapie génique.

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