Rescue agents for treating botulinum toxin intoxications

Details Rescue agents for treating botulinum toxin intoxications Rescue agents for treating botulinum toxin intoxications

A - Human Necessities

61

K

A61K 39/08 (2006.01) A61K 49/08 (2006.01) C07H 21/04 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2546383

The present invention relates to rescue agents for use in the treatments of toxin intoxication-for example botulinum intoxication, which can result from food poisoning, an act of bioterrorism, or from accidental overdose in the course of treatment. In some embodiments, the rescue agents comprise at least one of an inactive botulinum toxin and a modified nontoxic nonhemagglutinin. The present invention also provides for glycosylated active and inactive toxins and methods of using same.

La présente invention concerne des <= agents de sauvetage >= utilisés dans les traitements d'intoxication par une toxine, par exemple, une intoxication botulinique qui peut provenir d'un empoisonnement alimentaire, d'un acte de bioterrorisme ou d'une surdose accidentelle au cours d'un traitement. Dans certains modes de réalisation, ces agents de sauvetage contiennent au moins une toxine botulinique inactive et une protéine non toxique et non hémagglutinante (NTNH) modifiée. Ladite invention aussi pour objet des toxines inactives et actives glycosylées et leurs méthodes d'utilisation.

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