Resin particle, medical material and pharmaceutical...

Details Resin particle, medical material and pharmaceutical... Resin particle, medical material and pharmaceutical...

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2208571

A resin particle is provided which comprises an ethylene vinyl alcohol copolymer and 5 to 90 % by weight of cilostazol incorporated therein, and has a particle size of not greater than 2,000 µm. The resin particle, upon being administered orally, allows the concentration of cilostazol in blood to be kept constant over an extended period of time and, therefore, remarkably alleviates side effects such as pain and headache which may otherwise be caused by rapid release of cilostazol into a body.

Cette invention se rapporte à une particule de résine, qui comprend un copolymère éthylène/alcohol de vinyle, et 5 à 90 % en poids de cilostazol incorporé dans ce polymère, et qui possède une grosseur des particules qui n'est pas supérieure à 2000 µm. Lorsqu'elle est administrée par voie orale, cette particule de résine permet de maintenir constante la concentration de cilostazol dans le sang pendant une période prolongée et, par conséquent, elle atténue notablement les effets secondaires, tels que douleurs et maux de tête, qui autrement risquent d'être provoqués par une libération rapide du cilostazol dans le corps.

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