Resolution of enantiomeric mixtures of .beta.-lactams

Details Resolution of enantiomeric mixtures of .beta.-lactams Resolution of enantiomeric mixtures of .beta.-lactams

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) C07D 205/08 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2610411

A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted Beta-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted Beta-lactam diastereomer or a mixture of C3-ester substituted Beta- lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.

L'invention concerne un nouveau procédé destiné à la résolution d'un mélange énantiomérique de .beta.-lactames à substitution hydroxyle en C3. Généralement, le mélange énantiomérique est traité avec un agent d'acylation de proline optiquement actif en vue de la formation d'un diastéréomère de .beta.-lactame à substitution ester en C3 ou d'un mélange de diastéréomères de .beta.-lactame à substitution ester en C3, une récupération sélective de l'énantiomère inaltéré ou de l'un des diastéréomères étant alors réalisée.

Affiliated with

Also associated with

Rating

Resolution of enantiomeric mixtures of .beta.-lactams does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Resolution of enantiomeric mixtures of .beta.-lactams, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Resolution of enantiomeric mixtures of .beta.-lactams will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1454088