Resolution of racemic derivatives of 5-(1-methyl-5-...

Details Resolution of racemic derivatives of 5-(1-methyl-5-... Resolution of racemic derivatives of 5-(1-methyl-5-...

C - Chemistry, Metallurgy

07

D

260/299, 260/266

C07D 487/04 (2006.01)

Patent

CA 1235699

TITLE OF THE INVENTION RESOLUTION OF RACEMIC DERIVATIVES OF 5-(1-METHYL-5-METHYLTHIOPYRROL-2-OYL)-1,2-DIHYDRO-3H- PYRROLO[1,2-a]PYRROLE-1-CARBOXYLIC ACID AND ANALOGS ABSTRACT OF THE INVENTION Racemic mixture of derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H- pyrrolo[1,2 a]pyrrole-1-carboxylic acid and analogs were resolved into pure 1- or d-isomers via concomi- tant isomerization and functional crystallization.

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