Resolution of racemic pantolactone

Details Resolution of racemic pantolactone Resolution of racemic pantolactone

C - Chemistry, Metallurgy

07

D

260/374.6

C07D 307/32 (2006.01) C07D 307/33 (2006.01)

Patent

CA 1056388

ABSTRACT OF THE DISCLOSURE: A process for resolving racemic .alpha.-hydroxy-.beta.,.beta.-dimethyl-?-butyrolactone, referred to as D,L- pantolactone, into its optical antipodes, based on the sepa- ration of diastereomeric salts of D,L-pantoic acid (.alpha.,?-dihydroxy- .beta.,.beta.-dimethylbutyric acid), produced from D,L-pantolactone, by means of (-)-3-aminomethylpinane, (+)-3-aminomethylpinane or one of their acid addition salts, as a new resolving agent.

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