C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/34 (2006.01)
Patent
CA 2272716
A process for preparing an enantiomerically-enriched form of threo-retalinic acid which comprises resolving a mixture of enantiomers of a salt of the acid, said salt being formed with an achiral acid or base using a chiral resolving agent. The resolved salt can be esterified, to give the therapeutic agent d-thero-mehylphenidate.
La présente invention concerne un procédé permettant de préparer une forme enrichie énantiomériquement d'acide thréo-ritalinique, lequel procédé consiste à dédoubler un mélange d'énantiomères d'un sel de l'acide, ledit sel étant formé avec un acide ou une base achirale, à l'aide d'un agent séparateur chiral. Le sel dédoublé peut être estérifié, de manière à obtenir l'agent thérapeutique d-thréo-méthylphénidate.
Potter Gerard Andrew
Zavareh Hooshang Shahriari
Borden Ladner Gervais Llp
Medeva Europe Limited
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