Resolution of the enantiomers of amlodipine

Details Resolution of the enantiomers of amlodipine Resolution of the enantiomers of amlodipine

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01) C07B 55/00 (2006.01)

Patent

CA 2416062

The invitation provides an efficient method for the resolution of (R)-(+)- (formula (I)) and (S)-(-)(formula (II))-enantiomers of amlodipine, where the chiral reagent for resolution is tartaric acid and the chiral auxiliary reagent for resolution is deuterated dimethyl sulphoxide (DMSO-d6).

L'invention concerne un procédé efficace de résolution de (R)-(+)- (formule (I)) et (S)-(-)- (formule (II)) énantiomères d'amlodipine, où le réactif chiral pour la résolution est un acide tartarique et le réactif auxiliaire chiral pour la résolution est un diméthyl sulfoxyde deutéré (DMSO-d¿6?).

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