C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) C12P 13/00 (2006.01) C12P 13/02 (2006.01)
Patent
CA 2170059
A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.
Un procédé de production d'amines primaires et secondaires optiquement actives à partir des racémates correspondants se caractérise en ce que (a) on acyle énantiosélectivement une amine racémique en présence d'une hydrolase avec un ester dont le composant acide porte un atome de fluor, d'azote, d'oxygène ou de soufre à proximité de l'atome de carbone du carbonyle; (b) on sépare le mélange d'amine optiquement active et d'amine acylée optiquement active pour obtenir un énantiomère d'amine; et (c) on extrait le cas échéant de l'amine acylée l'autre énantiomère de l'amine par clivage de l'amide.
Balkenhohl Friedhelm
Hauer Bernhard
Ladner Wolfgang
Nubling Christoph
Pressler Uwe
Basf Aktiengesellschaft
Robic
LandOfFree
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