Resolution/racemization of aminolactam compounds

Details Resolution/racemization of aminolactam compounds Resolution/racemization of aminolactam compounds

C - Chemistry, Metallurgy

07

D

260/241.65, 260/

C07D 223/10 (2006.01) C07D 223/12 (2006.01)

Patent

CA 1051889

ABSTRACT OF THE DISCLOSURE Resolution of .alpha.-amino-.epsilon.-caprolactam with simultaneous racemization of the undesired .alpha.-aminocaprolactam enantiomer is effected by preferentially crystallizing the L- (or D-) .alpha.-amino- caprolactam compound in the presence of a racemization catalyst. In a narrower embodiment racemization of .alpha.-amino-.epsilon.-caprolactam is effected by alternate routes of forming a coordinately saturated aminolactam-metal complex and reacting with a strong base or reacting a mixture of an aminolactam salt and aminolactam free base with a chelating carbonyl compound and a metal ion or reacting a mixture of an aminolactam salt and aminolactam free base in the presence of a salen derivative complex.

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