Resorbable implant materials

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/24 (2006.01) A61L 27/22 (2006.01) A61L 27/36 (2006.01) A61L 31/04 (2006.01)

Patent

CA 2384961

A non-crosslinked, decellularized and purified mammalian tissue (e.g., bovine pericardium) having particular use as an implantable resorbable material. The material is treated by alkylating its primary amine groups in a manner sufficient to reduce the antigenicity of the tissue, permitting the treated tissue to be used in vivo and without crosslinking, and in turn, permitting it to be resorbable. The material can be used in surgical repair of soft tissue deficiencies for a certain period of time while the implant itself is gradually remodeled or absorbed by the host. Also provided are a method of preparing such a material as well as a method of using such a material for surgical repair.

L'invention concerne un tissu mammalien non réticulé, décellularisé et purifié (p. ex. le péricarde bovin), qui convient particulièrement comme matériel d'implantation possédant un pouvoir de résorption. Ce matériel est traité par alkylation de ses groupes amine primaires, de façon propre à réduire l'antigénécité du tissu. Le matériel traité est ensuite utilisé in vivo, sans réticulation, mais avec un pouvoir de résorption. Le matériel de l'invention peut être utilisé en chirurgie réparatrice pour corriger des défauts du tissu mou, durant une certaine période, pendant que l'implant lui-même est graduellement remodelé ou absorbé par l'hôte. L'invention concerne en outre un procédé de préparation dudit matériel, ainsi qu'un procédé d'utilisation dudit matériel à des fins de chirurgie réparatrice.

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