Resorption-controlled bone implants

Details Resorption-controlled bone implants Resorption-controlled bone implants

A - Human Necessities

61

L

A61L 24/00 (2006.01) A61L 27/12 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01)

Patent

CA 2468581

Biomaterials useful to induce the local growth and/or repair of bone tissue are described. The biomaterials incorporate a resorbable matrix doped with an inhibitor of cell-mediated acidification to control the rate at which the matrix is resorbed in vivo. In embodiments, the matrix is a near ambient CAP cement, and the inhibitor is a proton pump inhibitor, such as a macrolide- based antibiotic, especially bafilomycin.

L'invention concerne des biomatériaux utilisés pour induire une croissance locale et/ou réparer un tissu osseux. Lesdits biomatériaux incorporent une matrice résorbable dopée à l'aide d'un inhibiteur d'acidification à médiation cellulaire afin de réguler la vitesse à laquelle ladite matrice est résorbée in vivo. Dans certains modes de réalisation, la matrice est un ciment à base de calcium de phosphate se formant à la température du corps, et l'inhibiteur est un inhibiteur de la pompe à proton, tel qu'un antibiotique à base de macrolide, notamment la bafilomycine.

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