Respiratory syncytial virus renders dendritic cells tolerogenic

A - Human Necessities – 61 – K

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Details

A61K 39/12 (2006.01) A61P 3/10 (2006.01) A61P 19/02 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2728423

The present invention includes compositions, methods and systems for inducing immune tolerance using antigen presenting cells by infecting isolated antigen presenting cells with an effective amount of respiratory syncytial virus (RSV) or por-tions thereof sufficient to infect the antigen presenting cells and contacting CD4+, CD8+ or both CD4+ T cells and CD8+ T cells with the RSV-infected antigen presenting cells, wherein the CD4+, CD8+ or both CD4 and CD8+ T cells are rendered tolerogenic as measured in vitro by a mixed leukocyte reaction.

La présente invention concerne des compositions, procédés et systèmes pour induire une tolérance immunitaire à laide de cellules présentant lantigène par infection de cellules présentant lantigène isolées avec une quantité efficace de virus syncytial respiratoire (RSV) ou de parties de celui-ci suffisantes pour infecter les cellules présentant lantigène et mise en contact de cellules T CD4+, CD8+ ou à la fois de cellules T CD4+ et CD8+ avec les cellules présentant lantigène infecté par RSV, les cellules T CD4+, CD8+ ou à la fois les cellules T CD4+ et CD8+ étant rendues tolérogéniques telles que mesurées in vitro par une réaction de leucocytes mixtes.

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