Responsive microgel and methods related thereto

Details Responsive microgel and methods related thereto Responsive microgel and methods related thereto

A - Human Necessities

61

K

A61K 47/32 (2006.01) A61K 9/16 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2474711

A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of 'dangling chains' and wherein the 'dangling chains' of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substanially linear and sustained release of the therapeutic entity under physiological conditions.

L'invention concerne un microgel sensible répondant de manière volumétrique et réversible à un changement d'une ou plusieurs conditions aqueuses sélectionnées dans le groupe constitué par la température, le pH et les conditions ioniques. Ledit microgel est constitué d'un réseau ionisable de monomères homopolymères réticulés par covalence, ledit réseau ionisable étant relié par covalence à un copolymère amphiphile afin de former une pluralité de chaînes <=flottantes>=, et ces chaînes <=flottantes>= de copolymère amphiphile formant des agrégats immobiles de type micelles dans une solution aqueuse. Ledit microgel sensible comprend au moins une entité thérapeutique et distribue cette entité thérapeutique de manière prolongée et sensiblement linéaire dans des conditions physiologiques.

Affiliated with

Also associated with

Rating

Responsive microgel and methods related thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Responsive microgel and methods related thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Responsive microgel and methods related thereto will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1642466