Resurfacing of rodent antibodies

Details Resurfacing of rodent antibodies Resurfacing of rodent antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/46 (2006.01) G01N 23/20 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2105644

The present invention relates to the development of prediction rules that can be used to accurately model the variable regions of antibodies. A statistical analysis is presented which is based on accessibility calculated for a range of antibody crystal structures. When this information is applied to an antibody sequence database, it is possible to discriminate between human and murine antibodies at the sequence level purely on the basis of their surface residue profiles. A humanized rodent antibody that gives the appearance of a human antibody is predicted by substituting the set of surface exposed amino acid residues from the rodent antibody or fragment thereof with the set of surface exposed amino acid residues from the human antibody. A three dimensional model can then be constructed from the resulting, fully substituted variable region of the rodent antibody or fragment thereof.

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