Resuspendable coated magnetic particles and stable magnetic...

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H01F 1/06 (2006.01) A61K 49/18 (2006.01) B03C 1/01 (2006.01) G01N 33/543 (2006.01) G01N 33/553 (2006.01) H01F 1/44 (2006.01)

Patent

CA 2060182

Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging; are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic starting material in the presence of a coating material, such that coating can take place during the disruption. The particles are generally coated in suspension yielding a stable suspension of subdivided particles. With the proper selection of a coating material, preferably a protein or other biochemically or biologically active polymer such as an antibody, a resuspendable (colloidal) bioactive product is obtained.

Des suspensions stables de particules magnétiques enrobées, préférablement de particules bioactives pouvant être remises en suspension et particulièrement utiles en imagerie à résonnance magnétique, sont produites par rupture de ce qu'on pense être des agglomérats cristallins d'un matériau de départ voisin, à particules magnétiques, en présence d'un matériau d'enrobage tel que cet enrobage se produise au cours de la rupture. Les particules sont généralement enrobées en suspension produisant ainsi une suspension stable de particules subdivisées. En choisissant avec discernement le matériau d'enrobage, préférablement une protéine ou un autre polymère actif au niveau biochimique ou biologique comme un anticorps, on obtient un produit bioactif pouvant être remis en suspension (colloïdal).

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