Resveratrol-containing compositions for modulating gene...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/05 (2006.01) A61K 31/6615 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2699908

The present invention relates to a resveratrol-containing composition capable of modulating gene expression to an extent greater than that observed with resveratrol alone or with calorie restriction. The invention particularly pertains to such resveratrol-containing compositions that comprise resveratrol, a chelator, hyaluronic acid, and/or vitamin D and which upon administration to a recipient, increases the concentration or activity of a survival/longevity gene product and/or decreases the concentration or activity of a gene product that induces or causes cellular damage. Most preferably, the resveratrol-stabilizing composition will comprise the chelator phytic acid (inositol hexaphosphate; IP6), hyaluronic acid, and vitamin D. The invention further pertains to the use of such compositions in the treatment or prevention of cancer, cardiovascular disease, diseases associated with aging, and other conditions and illnesses.

La présente invention concerne une composition contenant du resvératrol capable de moduler l'expression d'un gène dans une mesure plus importante que celle observée avec le resvératrol seul ou avec une restriction de calories. L'invention concerne particulièrement de telles compositions contenant du resvératrol qui renferment du resvératrol, un chélateur, de l'acide hyaluronique et/ou de la vitamine D et qui après administration à un receveur, augmentent la concentration ou l'activité d'un produit génique de survie/longévité et/ou diminuent la concentration ou l'activité d'un produit génique qui induit ou provoque des dommages cellulaires. Idéalement, la composition stabilisant le resvératrol renfermera de l'acide phytique chélateur (inositol hexaphosphate ; IP6), de l'acide hyaluronique et de la vitamine D. L'invention concerne en outre l'utilisation de telles compositions dans le traitement ou la prévention du cancer, de maladies cardiovasculaires, de maladies associées au vieillissement et d'autres affections et pathologies.

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