C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.22
C12N 15/62 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01)
Patent
CA 1341422
A novel retinoic acid receptor is disclosed. The novel receptor is encoded for by cDNA carried on plasmid phRAR1, which has been deposited with the American Type Culture Collection for patent purposes. Chimeric receptor proteins are also disclosed. The chimera are constructed by exchanging functional domains between the glucocorticoid, the mineralocorticoid, the estrogen-related, the thyroid and the retinoic acid receptors. In addition, a novel method for identifying functional ligands for receptor proteins is disclosed. The method, which takes advantage of the modular structure of the hormone receptors and the idea that the functional domains may be interchangeable, replaces the DNA-binding domain of a putative novel receptor with the DNA-binding domain of a known receptor such as the glucocorticoid receptor. The resulting chimeric construction, when expressed in cells, produces a hybrid receptor whose activation of a ligand-(e.g., glucocorticoid) inducible promoter is dependent on the presence of the new ligand. The novel method is illustrated in part by showing that the ligand for the new receptor protein is the retinoid, retinoic acid.
584893
Evans Ronald Mark
Giguere Vincent
Ong Estelita Sebastian
Segui Prudimar Serrano
Thompson Catherine Caroline
Macrae & Co.
The Salk Institute For Biological Studies
LandOfFree
Retinoic acid receptor composition and method does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Retinoic acid receptor composition and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retinoic acid receptor composition and method will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1220621