Retinoid compounds and their use

Details Retinoid compounds and their use Retinoid compounds and their use

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 31/166 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/235 (2006.01) C07C 57/50 (2006.01) C07C 63/66 (2006.01) C07C 69/618 (2006.01) C07C 69/78 (2006.01) C07C 259/10 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2662218

The invention relates to retinoid compounds of one of the following formulae: Formula 6 a; R = H D1 R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 10 a,R = H b; R = Me (i) PaIa-CO2R' QC = H or Me) (ii)Imeta-CO2R' (R' = H or Me) (iii) ortho-CO2R' (R1 = H or Me) Formula 11 a; R = H b; R =Me (i) para-CONHOH (u)meta-CONHOH (ui)orttho-CONH0H Formula 12 (i) PaIa-CO2H (R = H or Me. R' = H or Me) (ii) meta-CO2H (R = H or Me, R' = H orM) Formula 13 R = H or Me, R' = H or M or a salt thereof, and to the use of such compounds in the control of cell differentiation.

L'invention concerne des composés rétinoïdes de formule (I), dans laquelle V est un groupe hydrophobe, W est un lieur non polyénique et X est un groupe polaire comprenant un donneur de liaison hydrogène, ou un sel de ces composés, ainsi que l'utilisation desdits composés pour réguler la différenciation cellulaire.

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