Retinoid-containing sustained release intraocular drug...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/07 (2006.01) A61K 31/203 (2006.01)

Patent

CA 2565285

Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

Des implants intraoculaires biocompatibles comprennent un composant rétinoïde et un polymère biodégradable qui est efficace pour faciliter la libération du composant rétinoïde dans l'oeil pendant une période de temps prolongée. Les agents thérapeutiques des implants peuvent être associés avec une matrice polymère biodégradable, telle qu'une matrice qui est sensiblement exempte d'alcool polyvinylique. Les implants peuvent être placés dans un oeil pour traiter ou réduire l'apparition d'un ou de plusieurs états oculaires, tels que dommages rétiniens, y compris, glaucome et vitréorétinopathie proliférative.

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