Retinoid pathway assays, and compositions therefrom

Details Retinoid pathway assays, and compositions therefrom Retinoid pathway assays, and compositions therefrom

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2429515

Methods for assaying a cellular pathway, and more particularly a retinoic acid- related pathway, are disclosed. The assays of the invention utilize particular host cells with desired retinoic acid pathway elements, and results in the identification of bilogically active phenotypic probes and cellular targets and fragments, variants and mimetics thereof.

L'invention concerne des méthodes de dosage d'une voie cellulaire, et plus spécifiquement, d'une voie afférente à l'acide rétinoïque. Les dosages de cette invention utilisent des cellules hôtes spécifiques avec des éléments de voies d'acide rétinoïque, ainsi que des résultats d'identification des sonde phénotypiques actives biologiquement et de fragments et cibles cellulaires, des variants et des substances mimétiques correspondantes.

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