Retinoid solutions and formulations made therefrom

Details Retinoid solutions and formulations made therefrom Retinoid solutions and formulations made therefrom

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 47/08 (2006.01)

Patent

CA 2586798

Compositions for topical application for treating a skin disorder (e.g., acne) include a retinoid, which is solubilized completely in alcohol only with the aid of cosolvents such as esters (e.g., alkyl benzoate, isopropyl palmitate, isopropyl myristate, diisopropyl adipate and their derivatives). This completely solubilized retinoid can be used to formulate an emulsion system or liquid to powder suspension containing a second active, such as an antibiotic (e.g., clindamycin) or benzoyl peroxide.

Compositions conçues pour être appliquées de façon topique afin de traiter une maladie de la peau (par exemple, l'acné) et contenant un rétinoïde solubilisé totalement dans l'alcool seulement à l'aide de cosolvants, tels que des esters (par exemple, alkyle benzoate, isopropyle palmitate, isopropyle myristate, diisopropyle adipate et leurs dérivés). Ce rétinoïde complètement solubilisé peut être utilisé afin de formuler un système d'émulsion ou une suspension liquide à pulvérante contenant un deuxième agent actif, tel qu'un antibiotique (par exemple, clindamycine) ou benzoyle peroxyde.

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