C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 403/20 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/225 (2006.01) A61K 31/44 (2006.01) A61P 1/00 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07C 403/10 (2006.01) C07D 213/30 (2006.01) C07D 213/55 (2006.01) C07D 239/26 (2006.01) C07D 307/42 (2006.01) C07D 333/38 (2006.01) C11C 3/00 (2006.01)
Patent
CA 2258593
This invention relates to the novel retinoyloxy(substituted)alkylene butyrate compounds and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment by comprising administering those compounds, pharmaceutically-acceptable salts or prodrugs thereof to a patient. The compounds of the invention are also useful in methods of inhibiting histone deacetylase, ameliorating wrinkles, treating or ameliorating dermatological disorders, inducing wound healing, treating cutaneous ulcers and treating gastrointestinal disorders.
L'invention concerne de nouveaux composés de rétinoyloxy-alkylène butyrate (substitué) et des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes permettant de traiter, de prévenir le cancer ou de soulager les symptômes du cancer et d'autres maladies prolifératives chez un sujet ayant besoin d'un tel traitement. La méthode consiste à administrer à un patient ces composés, leurs sels ou leurs promédicaments pharmaceutiquement acceptables. Les composés de l'invention sont également utiles dans des méthodes permettant d'inhiber l'histone déacétylase, d'atténuer les rides, de traiter ou de soulager les troubles dermatologiques, de favoriser la cicatrisation, de traiter les ulcères cutanés et les troubles gastro-intestinaux.
Nudelman Abraham
Rephaeli Ada
Bar-Ilan University
Kupat Holim Health Insurance Institution Of The General Federati
Smart & Biggar
LandOfFree
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