C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
530/5.04, 260/46
C07C 229/34 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07C 271/10 (2006.01) C07K 5/02 (2006.01) C07K 5/062 (2006.01) C07K 5/083 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2015053
CASE 3035 NEW RETRO-INVERSE, ONE- OR MORE-BOND BEARING ANALOGUES OF THYMOPENTIN, A METHOD FOR SYNTHESIZING THE SAME AND THEIR EMPLOYMENT FOR THE PREPARATION OF PHARMACEUTICAL ABSTRACT New thymopentin (TP5) analogues are disclosed which contain in their peptide chain one or more retro-inverse bonds. The new compounds have one of the following general formulas (I), (II) and (III) Image (I) Image (II) - 2 - Image (III) wherein R is hydrogen or an acyl radical, and R1 is a group of the formula -OR2 wherein R2 is a hydrogen atom or a hydrocarbon radical, and the corresponding acid or basic addition salts pharmaceutically acceptable. Such new compounds have immunostimulating activity.
Mariotti Sabina
Nencioni Luciano
Pessi Antonello
Sisto Alessandro
Verdini Antonio S.
Robic
Sclavo S.p.a.
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