C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 7/02 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349290
Retro-invension forms of GIT targeting agents that target specific receptor sites in vivo and/or promote uptake of active agents and/or enhance active agent delivery across the GIT into the systemic circulation are provided. These retro-inverted peptides and compositions containing these retro-inverted peptides can be used to deliver an active agent, such as a drug or a drug- containing nano- or microparticle for treatment of a condition in a subject in need of the drug, in vivo. Additionally, the invention provides antibodies which are capable of immunospecifically binding the retro-inverted peptides.
L'invention concerne des formes rétro-inverses d'agents ciblant le tractus gastro-intestinal se liant à des sites récepteurs spécifiques $iiin vivo) et/ou favorisant l'absorption d'agents actifs et/ou l'apport d'agents actifs dans la circulation systémique. Ces peptides rétro-inverses et les compositions renfermant lesdits peptides peuvent être utilisés pour véhiculer un agent actif, tel qu'un médicament ou une nano ou micro-particule renfermant un médicament, en vue du traitement d'une pathologie chez un sujet nécessitant ce médicament, in vivo. En outre, l'invention concerne des anticorps capables de se lier de manière immunospécifique à ces peptides rétro-inverses.
Elan Corporation Plc
Kirby Eades Gale Baker
Merrion Research III Limited
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