C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.14
C07K 7/14 (2006.01) C07K 5/02 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1249699
A RETRO-INVERSO ANALOGUE OF THE (5-14) DECAPEPTIDE OF EQUINE ANGIOTENSINOGEN, AS A SPECIFIC RENIN INHIBITOR WITH HIGH RESISTANCE TO ENZYMATIC HYDROLYSIS ABSTRACT Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Val bond, of formula: Pro-His-Pro-Phe-His-Phe-NH- Image -NH-CO- Image -CO-Tyr-Lys The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.
454917
Pinori Massimo
Verdini Antonio S.
E.n.i. Ente Nazionale Idrocarburi
Robic Robic & Associes/associates
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