C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.1, 167/103
C07K 14/66 (2006.01) A61K 38/22 (2006.01) C07K 5/02 (2006.01) C07K 5/10 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2006561
CASE 2978 NEW RETRO-INVERSO ANALOGUES Of THYMOPENTIN, THE METHOD FOR THEIR SYNTHESIS AND THEIR USE IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS. ABSTRACT New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP51-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described. The new compounds, of general formula (I) Image (I) where R is hydrogen or an acyl radical, and R1 is an -OR2 group or an Image group where R2 is a hydrogen atom or a hydrocarbon radical, and R3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
Mariotti Sabina
Nencioni Luciano
Sisto Alessandro
Verdini Silvio
Villa Luigi
Mariotti Sabina
Nencioni Luciano
Robic Robic & Associes/associates
Sclavo S.p.a.
Sisto Alessandro
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