Retro-inverso neurotrophic and analgesic peptides

Details Retro-inverso neurotrophic and analgesic peptides Retro-inverso neurotrophic and analgesic peptides

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2300221

Retro-inverso peptide analogs derived from the active neurotrophic region of saposin C. The saposin C-derived peptides (prosaptides) induce neurite outgrowth in vitro, prevent programmed cell death, induce myelination and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and pain management. The retro-inverso peptides are significantly more resistant to metabolic degradation than the corresponding non-inverted peptides.

La présente invention concerne des analogues de peptide rétro-inverse dérivés de la région neurotrophique active de la saposine C. Les peptides dérivés de la saposine C (prosaptides) produisent une excroissance de neurite in vitro, empêchent la mort cellulaire programmée, entraînent la myélinisation et ont un effet analgésique. Ces peptides sont utilisés dans le traitement des troubles du système nerveux périphérique et dans la gestion de la douleur. Ces peptides rétro-inverses sont significativement plus résistants à une dégradation métabolique que les peptides non inverses correspondants.

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