Retro-inverso peptides derived from interleukin-3

Details Retro-inverso peptides derived from interleukin-3 Retro-inverso peptides derived from interleukin-3

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2376394

Retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-3 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation <i>in vivo</i>.

L'invention concerne des peptides rétro-inverso dérivés de l'interleukine-3 (IL-3), qui possèdent entre 12 et 40 acides aminés et comprennent la séquence montrée en SEQ ID NO: 1. Ces peptides possèdent la même activité que l'interleukine-3 (IL-3), d'origine et également l'activité neurotrophique. Grâce à la liaison D amino-acide présente dans ces peptides, ceux-ci sont moins susceptibles de subir une dégradation protéolytique <i>in vivo</i>.

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