Retro-inverso peptides derived from interleukin-6

Details Retro-inverso peptides derived from interleukin-6 Retro-inverso peptides derived from interleukin-6

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 7/02 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2376479

Retro-inverso peptides derived from interleukin-6 (IL-6) having between 17 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-6 and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation <i>in vivo</i>.

Ces peptides rétro-inverses dérivés de l'interleukine 6 (IL-6) possèdent entre 17 et 40 acides aminés environ et renferment la séquence illustrée par SEQ ID N·: 1. Ces peptides, qui ont la même activité que l'IL-6 endogène, ont également une activité neurotrophique. La présence de la liaison génétique aminoacide de type D dans ces peptides les rend moins sujets à un dégradation protéolytique <i>in vivo</i>.

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