Retro-inverso peptides derived from leukemia inhibitory factor

Details Retro-inverso peptides derived from leukemia inhibitory factor Retro-inverso peptides derived from leukemia inhibitory factor

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C07K 7/02 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2376474

Retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native LIF and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation <i>in vivo</i>.

L'invention concerne les peptides rétro inverses dérivés du facteur d'inhibition de la leucémie (LIF) possédant entre 18 et environ 40 acides aminés et comprenant la séquence représentée dans SEQ ID NO : 1. Ces peptides ont la même activité que le LIF natif ainsi qu'une activité neurotrophique. Du fait de la liaison des acides aminés D dans les peptides, ces peptides sont moins sensibles à la dégradation protéolytique <i>in vivo</i>.

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