Retroviral packaging cell line

Details Retroviral packaging cell line Retroviral packaging cell line

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/44 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01) C12N 9/16 (2006.01)

Patent

CA 2324028

The present invention provides packaging cell lines and recombinant lentiviral or retroviral particles produced therefrom, particularly pseudotyped retroviral particles. The packaging cell lines of the invention are produced by inducibly expressing an envelope protein by methods described herein. Also described is a screening assay for compounds that affect integration of viral nucleic acid into target (e.g., host) nucleic acid. Such compounds are identified based on their effect on viral integrase.

L'invention porte sur des lignées de cellules d'encapsidation, sur les particules lentivirales de recombinaison ou rétrovirales qu'elles produisent, et en particulier sur des particules rétrovirales pseudotypées. Les lignées de cellules d'encapsidation de l'invention sont obtenues par induction de l'expression d'une protéine enveloppe par des méthodes présentées dans la description. L'invention porte également sur un essai de criblage en vue de la sélection de composés agissant sur l'intégration à des acides nucléiques cibles (par exemple hôtes) d'acides nucléiques viraux, lesdits composés étant identifiés par leurs effets sur l'intégrase virale.

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