Retroviral packaging cell line

Details Retroviral packaging cell line Retroviral packaging cell line

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2604824

The present invention provides packaging cell lines and recombinant lentiviral or retroviral particles produced therefrom, particularly pseudotyped retroviral particles. The packaging cell lines of the invention are produced by inducibly expressing an envelope protein by methods described herein. Also described is a screening assay for compounds that affect integration of viral nucleic acid into target (e.g., host) nucleic acid. Such compounds are identified based on their effect on viral integrase.

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