Retroviral packaging cell line

Details Retroviral packaging cell line Retroviral packaging cell line

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) C07K 14/15 (2006.01) C07K 14/73 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/40 (2006.01) C12N 15/64 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2092195

The invention described herein allows the production of recombinant retroviruses (retroviral vector particles) from producer cells which are safer and of higher titre than normal. In addition, methods are provided for making helper cells which, when a recombinant retrovirus genome is introduced to make a producer line, produce particles that are targeted toward particular cell types. Methods are also provided for making recombinant retrovirus systems adapted to infect a particular cell type, such as a tumor, by binding the retrovirus or recombinant retrovirus in the particular cell type. Methods are also provided for producing recombinant retroviruses which integrate in a specific small number of places in the host genome, and for producing recombinant retroviruses from transgenic animals.

L'invention permet la production de rétrovirus recombinés (particules vectorielles rétrovirales) à partir de cellules productrices plus sûres et d'un titre supérieur à la normale. De plus, l'invention concerne des procédés de production de cellules auxiliaires qui, lorsqu'un génome de rétrovirus recombiné est introduit afin de produire une lignée productrice, produisent des particules dont les cibles sont des types particuliers de cellules. De plus, l'invention concerne des procédés de production de systèmes de rétrovirus recombinés adaptés pour infecter un type particulier de cellules, tel qu'une tumeur, par liaison du rétrovirus ou du rétrovirus recombiné dans le type particulier de cellules. En outre, l'invention concerne des procédés de production de rétrovirus recombinés s'intégrant dans un petit nombre spécifique d'endroits dans le génome hôte, et des procédés de production de rétrovirus recombinés à partir d'animaux transgéniques.

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