Retroviral particles protected against complement mediated...

Details Retroviral particles protected against complement mediated... Retroviral particles protected against complement mediated...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01) C12N 15/48 (2006.01) C12N 15/867 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2343090

The present invention relates to retroviral particles which are specifically applicable as safe gene transfer vehicles for targeted gene therapy and which are protected against complement mediated destruction in host organisms. For producing such retroviral particles a packaging cell is provided according to the present invention comprising a DNA construct coding for one or more complement inhibitors. Said inhibitors are derived from the complement system of the organism to be infected by the retroviral particle generated by the packaging cell.

L'invention concerne des particules rétrovirales utilisables spécifiquement comme véhicules fiables pour le transfert de gènes en thérapie génique ciblée. Ces particules sont protégées contre la destruction dont la médiation est assurée par le complément dans les organismes hôtes. En vue d'élaborer lesdites particules, on fournit une cellule d'encapsidation à codage de construction d'ADN pour un ou plusieurs inhibiteurs de complément. Les inhibiteurs considérés sont dérivés du système du complément de l'organisme destiné à être infecté par la particule rétrovirale issue de la cellule d'encapsidation.

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