Retroviral protease inhibiting compounds

Details Retroviral protease inhibiting compounds Retroviral protease inhibiting compounds

C - Chemistry, Metallurgy

07

D

C07D 239/10 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) C07D 207/27 (2006.01) C07D 207/404 (2006.01) C07D 207/408 (2006.01) C07D 233/36 (2006.01) C07D 233/42 (2006.01) C07D 239/22 (2006.01) C07D 241/18 (2006.01) C07D 253/06 (2006.01) C07D 263/22 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2238977

Inhibitors of HIV protease are provided. When bound to HIV protease, the inhibitors are characterized by a unique three-dimensional conformation and orientation relative to the S1, S1', S2, S2', S3, and S3' subsites of the protease. Pharmaceutical compositions containing the inhibitors and methods of treating HIV infection are also provided.

La présente invention concerne des inhibiteurs de protéases du VIH. Lorsqu'ils sont liés à une protéase du VIH, ces inhibiteurs sont caractérisés par une conformation et une orientation tridimensionnelles uniques par rapport aux sous-sites S1, S1', S2, S2', S3 et S3' de la protéase. L'invention concerne également des compositions pharmaceutiques contenant ces inhibiteurs et des procédés de traitement contre l'infection VIH.

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