Retroviral protease inhibiting compounds

Details Retroviral protease inhibiting compounds Retroviral protease inhibiting compounds

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/33 (2006.01) A61K 38/04 (2006.01) C07C 53/134 (2006.01) C07C 215/18 (2006.01) C07C 215/20 (2006.01) C07C 215/28 (2006.01) C07C 233/40 (2006.01) C07C 237/10 (2006.01) C07C 237/22 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 271/34 (2006.01) C07C 275/24 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/34 (2006.01) C07D 213/40 (2006.01) C07D 213/54 (2006.01) C07D 213/56 (2006.01) C07D 213/61 (2006.01) C07D 213/75 (2006.01) C07D 233/54 (2006.01) C07D 233

Patent

CA 2055670

A retroviral protease inhibiting compound is diclosed. The compound is of the formula (see Formula I) wherein R1 is hydrogen and R2 and R3 are independently selected from C6-aryl-C1-to-C6-alkyl, C9-to-C10-aryl-C1-to-C6-alkyl, C3-to-C7- cycloalkyl-C1-to-C6-alkyl and (heterocyclic)-C1-to-C6-alkyl; and A and B are independently selected from R6-C(O)-(NH)-(CH(R5))- C(O)- and R6-C(O)- wherein at each occurrence R6 is independently selected from R7-N(C1-to-C6-loweralkyl)-, R7-O- and R7-S- wherein R7 is heterocyclic or (heterocyclic)-C1-to-C6-alkyl and at each occurrence R5 is independently selected from C1-to-C6-loweralkyl; or a pharmaceutically acceptable salt, thereof. Also disclosed are a composition use and kit for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.

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