Retroviral protease inhibitors

Details Retroviral protease inhibitors Retroviral protease inhibitors

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 7/06 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/04 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2005340

4-17359/+ Retroviral protease inhibitors Abstract The invention relates to compounds of the formula Image (I), wherein AAN is a bivalent radical, consisting of from one to five bivalent .alpha.-amino acid residues, which is bonded N-terminally to the radical R2 and C-terminally to the group NH-, AAC is a bivalent radical, consisting of one or two bivalent a-amino acid residues, which is bonded N-terminally to the group -C=O and C-terminally to the radical R1, R1 is hydroxy, etherified hydroxy, amino or substituted amino with the excep- tion of an amino radical derived from an .alpha.-amino acid, and R2 is hydrogen or an acyl radical with the exception of an unsubstituted or N-substi- tuted acyl radical of a natural amino acid, and salts of such compounds having salt-forming groups. The compounds are suitable as gag-protease inhibitors.

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