Retroviral protease inhibitors

Details Retroviral protease inhibitors Retroviral protease inhibitors

C - Chemistry, Metallurgy

12

N

C12N 9/99 (2006.01) A61K 38/55 (2006.01) C07K 7/02 (2006.01) C12N 7/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2091151

X-8442 Abstract The present invention provides compounds that inhibit the action of retroviral proteases. These compounds incorporate transition-state residues at the core of low molecular weight peptide analogs and include naphthylalanine residues at both termini that enhance the compounds inhibitory capacity. Thus, the compounds can be used to inhibit retroviral proteases in a biological solution and prevent the processing of retroviral polyproteins. The compounds can also be used to inhibit the replication and maturation of retroviruses in cell culture or in vivo.

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