Retroviral superantigens, superantigen peptides, and methods...

Details Retroviral superantigens, superantigen peptides, and methods... Retroviral superantigens, superantigen peptides, and methods...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 39/395 (2006.01) C07K 14/15 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2175255

The subject invention concerns novel superantigen proteins and peptides and methods of use of these superantigens. Specifically exemplified are superantigen proteins and peptide antagonists and agonists from mouse mammary tumor virus, feline immunodeficiency virus and human immunodeficiency virus. The proteins and peptides can also be used to produce, purify and detect antibodies that bind to superantigens. These superantigens and their corresponding peptides can be used in both diagnostic and therapeutic protocols.

L'invention a pour objet de nouvelles protéines et de nouveaux peptides de super-antigènes et des procédés d'utilisation de ces super-antigènes. Elle décrit plus précisément des antagonistes et agonistes de protéines et peptides de super-antigènes provenant des virus de la tumeur mammaire de la souris, de l'immunodéficience féline et de l'immunodéficience humaine. Les protéines et peptides peuvent aussi être utilisés pour produire, purifier et détecter des anticorps qui se lient aux super-antigènes. Ces super-antigènes et les peptides correspondants peuvent être utilisés dans des protocoles de diagnostic et de traitement.

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