C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 35/36 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2150536
The invention relates to recombinant retroviral vectors, derived from Moloney MuLV, carrying a suicide gene susceptible of transforming an inactive substance into a toxic substance for cells going through a division process, said vectors being characterized by the presence in their structure of LTR sequences from variants of MuLV, and having the properties: (a) of not being inactivated during passage through the carcino-embryonic or line germinal cells of mice; (b) the expression of the suicide gene kills only the cells in the course of division.
L'invention corcerne des vecteurs rétroviraux recombinants, dérivés des Moloney MuLV, porteurs d'un gène suicide susceptible de transformer une substance inactive en substance toxique pour des cellules en division, et caractérisés par la présence dans leur structure de séquences LTR issues de variants du MuLV, ayant les propriétés: de ne pas étre inactivés lors d'un passage dans des cellules carcino-embryonnaires ou lignées germinales de souris; dont l'expression du gène suicide ne tue que les cellules en division.
Caruso Manuel
Klatzmann David
Fetherstonhaugh & Co.
Universite Pierre Et Marie Curie (paris Vi)
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