Retroviral vectors, methods for their preparation and their...

Details Retroviral vectors, methods for their preparation and their... Retroviral vectors, methods for their preparation and their...

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2282394

The invention relates to the production and use of retroviral vectors for cell- type specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of marine leukemia virus (MLV) and envelope proteins of human immunodeficiency viruses (HIV) or simian immunodeficiency viruses (SIV). Said vectors can be used for gene transfer in selected cell types, specially in CD4-positive mammal cells.

L'invention concerne la production et l'utilisation de vecteurs rétroviraux pour le transfert génique spécifique de types cellulaires, notamment un procédé de production de vecteurs rétroviraux contenant des particules de capside du virus de la leucémie murine et des protéines d'enveloppe de virus de l'immunodéficience humaine ou de virus de l'immunodéficience simienne. Ces vecteurs peuvent être utilisés pour le transfert génique dans des types de cellules sélectionnés, notamment dans des cellules mammaliennes positives CD-4.

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