C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/867 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2196208
Retroviral vectors which are resistant to inactivation by human serum. The retroviral vectors are produced in a cell line which is resistant to lysis by human serum, such cell lines including the HOS, Mv-1-Lu, HT1080, TE671, and human 293 cell lines, as well as cell lines derived therefrom. Such retroviral vectors are especially useful as in vivo gene delivery vehicles.
Vecteurs rétroviraux résistant à une inactivation par le sérum humain. Ces vecteurs rétroviraux sont produits dans une lignée cellulaire qui est résistante à la lyse par le sérum humain. Ces lignées cellulaires peuvent être des lignées de cellules HOS, Mv-1-Lu, HT1080, TE671 et des lignées de cellules humaines 293, ainsi que des lignées de cellules qui en sont dérivées. De tels vecteurs rétroviraux sont particulièrement utiles comme véhicules d'apport en gènes in vivo.
Collins Mary K. L.
Cosset Francois-Loic
Pensiero Michael
Takeuchi Yasuhiro
Weiss Robin A.
Fetherstonhaugh & Co.
Genetic Therapy Inc.
Institute Of Cancer Research-Royal Cancer Hospital
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