Retroviral vectors useful for gene therapy

Details Retroviral vectors useful for gene therapy Retroviral vectors useful for gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 38/37 (2006.01) A61K 38/46 (2006.01) A61K 38/49 (2006.01) A61L 27/38 (2006.01) A61L 33/18 (2006.01) C07K 14/635 (2006.01) C07K 14/705 (2006.01) C07K 14/755 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 9/38 (2006.01) C12N 9/72 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2095256

2095256 9207943 PCTABS00013 Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety of transfected cell types. Also disclosed are retroviral vectors lacking a selectable marker, thus rendering them suitable for human gene therapy in the treatment of a variety of disease states without the co-expression of a marker product, such as an antibiotic. These retroviral vectors are especially suited for use in certain packaging cell lines.

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